Pharm-Rx Paroxetine HCL Hemihydrate

Chemical Name: Paroxetine Hydrochloride Hemihydrate

CAS Number: 110429-35-1

Ask Pharm-Rx Chemical Corp. Questions

Mark Bostel avatar

    Enhanced TDS

    Identification & Functionality

    Chemical Name
    Molecular formula
    C₁₉H₂₀FNO₃ · HCl, C₁₉H₂₀FNO₃ · HCl · ½H₂O
    Technologies
    Product Families
    Chemical Structure

    Pharm-Rx Paroxetine HCL Hemihydrate - Chemical Structure - 1

    Definition

    Paroxetine Hydrochloride is anhydrous or contains one-half molecule of water of hydration. It contains NLT 98.5% and NMT 102.0% of paroxetine hydrochloride (C19H20FNO3 · HCl), calculated on the anhydrous and solvent-free basis.

    Applications & Uses

    Properties

    Typical Properties
    ValueUnitsTest Method / Conditions
    Molecular Weight365.83--
    Molecular Weight374.83--

    Regulatory & Compliance

    FDA Disclaimer

    These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

    USP Reference Standards

    USP Paroxetine Hydrochloride RS
    USP Paroxetine Related Compound B RS(3S,4R)-3-[(Benzodioxol-5-yloxy)methyl]-4-phenylpiperidine hydrochloride.
    C19H21NO3· HCl 347.84
    USP Paroxetine Related Compound C RS(3R,4S)-3-[(Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride;Also known as (+)-trans-Paroxetine hydrochloride.
    C19H20FNO3· HCl 365.83
    USP Paroxetine Related Compound E RS4-(4-Fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridinehydrochloride.
    C12H14FN · HCl 227.71
    [NOTE—Paroxetine related compound E was previous identified as 1-methyl-4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride.]
     

    USP Paroxetine Related Compound F RS (3S,4R)-3-[(Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methylpiperidine.
    C20H22FNO3 343.39

    USP Paroxetine Related Compound G RS (3SR,4RS)-3-[(Benzodioxol-5-yloxy)methyl]-4-(4′-fluorobiphenyl-4-yl)piperidine hydrochloride;Also known as(±)trans-3-[(1,3-Benzodioxol-5-yloxy) methyl]-4-(4′′-fluorophenyl-4′-phenyl)piperidine hydrochloride.
    C25H24FNO3· HCl 441.93

    USP Paroxetine System Suitability Mixture A RS
    Contains a mixture of the following three compounds: Paroxetine hydrochloride. Paroxetine related compound A: (3S,4R)-3- [(Benzodioxol-5-yloxy)methyl]-4-(4-methoxyphenyl)piperidine hydrochloride; Also known as piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-methoxyphenyl)-, hydrochloride (3S-trans)-.

    C20H23NO4∙HCl 377.86

    Paroxetine related compound B: (3S,4R)-3-[(Benzodioxol-5-yloxy)methyl]-4-phenylpiperidine hydrochloride;

    Also known as piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-phenyl-,hydrochloride (3S-trans)-.
    C19H21NO3∙HCl 347.84